How Psychedelics Change the Brain

49 Comments

1. Sister you are so honest I love you. 😘

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2. Had my first trip last weekend alone. OMG. Unreal. I thanked God for showing me what I saw. 🥰🥰🥰🥰 I can't believe I was ever against it. It wasn't at all what I was told it would be.

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3. I think the real risk with psychedelics is you very well could “rewire your brain” in ways you don’t want

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4. What people aren’t understanding on why psychedelics and weed is illegal and cigarettes and alcohol aren’t is not because of the health consequences because even the government knows that weed and shrooms are healthier on the body than nicotine and alcohol but it’s more so the mental consequences. And the annoying thing about psycho nuts and potheads is they usually disregard the negative mental health consequences even though it’s been proven many people have developed problems from those drugs and sometimes you gotta accept the negative consequences because those are more important than the positive ones. Of course we can talk about the positive outcomes of trying weed and using shrooms there’s plenty but you can’t overlook the minority of people that lives have been altered from these substances bringing out pre existing mental health problems that might’ve never happened if they didn’t take these drugs. Because those people matter and I think that’s why it’s illegal. There’s just less chance alcohol and cigarettes are going to cause mental health problems compared to shrooms and weed and trust me my mom was an alcoholic I know how bad alcohol can have a toll on your mental state but usually once you get sober these things recover and don’t last forever. A bad trip can cause permanent serious PTSD like symptoms in people especially the youth and thats scary. Remember it’s not about the health consequences it’s about the mental health ones.

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5. imagine tripping shrooms in a mri 😂😂

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6. Change the brain when you understand what youre changing in the first place. Until then its cart before horse. Did SSRIs not teach you anything?

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7. I’ve noticed I’ve been talking with a lot more people and random people at that I used to never want or been anxious to do so

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8. I got HPPD type 2 from psychedelics, they may be cool the first couple times but you get HPPD type 2 your life actually feels like it’s over, HPPD is actually the worst and most terrifying thing I’ve ever been through.

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9. They don’t change the brain they set the brain into default settings.

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10. Check my brain on an OZ please 😂

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11. And imagine how sublime they will be on someone who’s not doing it for some type of a cure or fix, but surely for the absolute pleasure of the experience

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12. Real scintific " Like a snow globe"

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13. Yes, they change the connection pattern, and it's very dangerous… for the system.

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14. I was on 100ug once (acid). That was single-handedly the most life changing experience I have ever had (more life-changing than my near-death experience in a pitch-black dark ocean drifting for 3 hours and got rescued) During that trip every single social norm was challenged and broken. The only thing that made sense to me then was that there is life and there is nothing. Death is the only thing that separates the two. And in this entire world, that is the only thing that matters. I had this trip for half a year now, and I remember to slowly get back the feeling of “myself” was very strange. Strange in a way that I know this feeling of “myself” is fake and purely just a delusional construct of my first-person narrative in my brain, but this feeling of “myself” is also nice and easy for me live the rest of my life. To be completely out of myself and reconstruct my entire world is hard and I might not be ready for it. But since the trip, I have been reshaping myself everyday. It is now very easy for me to only do things that I think is right to do and not do things that I don’t agree to. That trip truly ripped my brain and my identity apart completely in a way that I cannot express (you have to experience it yourself to know what I mean and that experience for sure is different for everybody.) The clarity that I am left with is the greatest gift I can ever ask for.

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15. It’s honestly crazy that he said it was the best headache that he ever had in his life because the first time I ever took mushrooms. I felt like I was having full body orgasms the whole time. It was amazing. But after I had the worst headache I’ve ever had in my life. I wonder how much it changed my brain and in what capacity

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16. Don't be fooled by the hype, it's not all nice flowers and sunshine, sometimes bad things happen… Sometimes you meet bad entities on DMT for instance, or become delirious and stuck in bad places or modes I guess on dissociatives, that being said, these are the best drugs that exist, they can have the most profound positive effects, I'm just saying remember there's a cost for everything, or, a risk at least

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17. My initial experience was truly remarkable.

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18. Psilocybin saved my life. My anxiety depression cptsd audhd ruled my life. I never felt peace, was stuck dwelling on bad experiences and repetitive frustration and pain. I was miserable all the time, I had to mask just to be around people and pretend to function. I was suicidal most of the time. Started psilocybin and did a few museum doses in btwn microdosing, and within a cpl of weeks, 85% of all of that faded away. It was like a surgical removal of broken parts of my psyche replaced with new improved pieces that fit perfectly. Anger, regret, sadness.. brought down to minimum manageable "normal" levels. It's as close to a miracle as I can imagine. I only have to redose every few weeks or months, just as needed.

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19. I started micro dosing medically and my PTSD was cured also i felt so much love for others and no fear. I don’t fear the dark or night anymore. I also kept feeling love for everyone. I felt like i was Hitler and I was his victims and I was me but I was also those i hate. We were all 1. I now see things very differently

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20. I've been trying to troll law enforcement facebook groups with links to this type of content and get censored almost instantly.

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21. The sad part of what I do is that I try to guide people to Psychedelics, the greatest thing imaginable, but they are so closedminded, so dogmatic, so arrogant that they will never reach it. The saddest part is that I know this perfectly well, I know exactly what they missed, but they have no clue. I have the saddest job in the world: leading people to the greatest thing imaginable, Infinite Love, for free, only to watch them reject the guidance out of sheer ignorance, closedmindedness, and pigheadedness. I see it every week, mind after mind rejecting Infinity. Just imagine, rejecting Psychedelics out of pure pigheadedness. What a loss! What a self-own! But what can I do? I can’t force Infinite Love on you.

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22. Psychedelics have the ability to induce profound altered states of consciousness

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23. My journey with psychedelics has been incredibly beneficial. They’ve played a major role in alleviating my anxiety and depression, significantly enhanced my mental health and quality of life.

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24. Psychedelics like psilocybin mushrooms are being studied for helping with mental health issues, but their effects vary, so caution and professional guidance are essential. Always consult a doctor before trying any treatment, and be aware of your local laws. Your safety comes first

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25. my studies have led me to understand our nature that we often push away due to survival needs. A emphasized reminder of how sensitive we truly are and how our surroundings can affect us

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26. Link to the full episode?

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27. psychedelics have crazy power to hep people its crazy how the government pushes anti depressants when psilocybin is a life changing cure for many. LEGALIZE PSYCHEDELICS FOR MEDICAL USE!!!

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28. PBS = BS because of woke management pack it up A.I. will expose you soon

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29. Απαρεονισα

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30. donny dRump needs a dose.

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31. I don't have time to wait for these old a holes to wake up!
    People i care for are suffering.
    only because of the stigma and long lasting status of these remedies, they'll be stuck in their misery until the day they die.

    as a person of the arts, i always knew these substances are to be respected and indeed they've helped me immensely. I just wish that path was less chaotic due to the illegality and ignorance that exists in the realms of the masses.

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32. “It’s like a snow globe “?
    No. It’s like experiencing the most of everything in your life. The worst and the best at the same time. Unexplainable in words.

    It’s neither good or bad and “science” still can’t figure it out.

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33. I free myself and overpass child traumas and bad parenthood examples in 3 trips. Im not taking lsd since 2019 but it was what i needed. I dont say that is a cure or that it will help every body. Go to a psycologist or doctor. And if you have Sever psiquiarric issues dont use it but if not give it a try in a cool place with good friends and see what you see about yourself. The hard part is accept what you really are see yourself as you are and learn of the bad to work on it and lean on the good to explore those sides of you

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34. How does deep meditation compare to psychedelics?

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35. I ❤ drugs 😂

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36. This could Unlock our Brain potential… Imagin the Designing abilities 😮👍🏼

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37. Psychedelics are truly revolutionary! Science is finally catching up to what ancient cultures have known for centuries—these substances have the power to heal and expand the mind.

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38. Anyone else on shrooms watching this

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39. READ kjv Revelation 1:14-15 in the bible. 👉Christ is described to have white wool hair & dark skin (thats what Christ YASHAYA really looks like) also 🖐🏿Daniel 10:5 & 6 .💠 Eyes like lamps of Fire 🔥 red. Like wine?
    👉💠 his arms & feet like a color of polished BRASS .
    & it does matter if the✡️ ppl (roman)) catholics converts gonna lie on Christ the 1st begotten on the father.
    ●bc what they show in Christianity is not what the bible says.
    ● & everybody knows what this 😈✡️ pentagram is ,.. star of Molock. Look up it. & their idolaters too. With all their idols. That has Nothing to do with the bible. Read Jeremiah 10.
    & read Deuteronomy 28-68 real Israelites were on slave ships to America.
    & in Revelation 2:9 Christ exposes the FAKE j3ws J3W–ISH✡️ppl. Aka ~{Romans}~ catholics & they believe in telmud & read the Kabbalah too. Those books are😈✡️. U can convert into a physical bloodline. There is no spiritual Israelites.
    (do your research) ✡️are esau, edomites 👉👈👈👉👉👈

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40. I call it human "developer mode". Glad to see its not just my imagination dreaming it up

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41. So, it turns out neuroscientists at California University have cracked the code on how to pick up a snow globe and give it a good shake. Mind-blowing, right? I mean, who knew that the complex mysteries of the brain could be unlocked by… well, giving a little shake to a snow globe? Move over, quantum physics it’s time to jiggle some snowflakes around. What’s next, a study on how to properly stir your coffee? Btw im on shrooms atm.

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42. anyone know where i can find the images of the mathematical model images of normal brain function and function under the influence of psychedelics?

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43. Long story short the shrooms get u to drop ur default mode network like the small talk we are used to keep us less ackward or like social niceties well that’s all gone and it feels like an illusion and you feel present and conscious source of power

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44. LSD made me stop most bad habits in a very short period of time. The first few times i took acid got me to quit cigs, after that energy drinks then softdrinks. i started training regularly, and now i stoped watching corn at all. this changed my life in only a few months. a few days i even stopped smoking weed so i can get my licence.

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45. I've consumed roughly 5 lbs over the last 2 1/2 years. I'm completely rewired and it continues to amaze me.

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46. Catecholamine hypotheses remain important for depression and mania
    
    The norepinephrine-deficiency hypothesis of depression had several roots: one observation concerned the natural alkaloid reserpine. Treatments involving reserpine had been used in India for centuries as a treatment for mental illness. Beginning in the 1950s, reserpine was used more widely for the treatment of hypertension and schizophrenia. It was noted that, in some patients, reserpine caused a syndrome resembling depression. Animals given reserpine also developed a depression-like syndrome, consisting of sedation and motor retardation. Subsequently, it was demonstrated that reserpine caused the depletion of presynaptic stores of NE, 5-HT and DA. While it is now recognized that depression is relatively uncommon following reserpine administration, the drug had a key role in the development of psychopharmacology and was a powerful impetus to the study of the biochemistry of neuroregulators in the brain.

    In contrast to reserpine, iproniazid, a compound synthesized in the 1950s for the treatment of tuberculosis, was reported to produce euphoria and hyperactive behavior in some patients. It was found to increase brain concentrations of NE and 5-HT by inhibiting the metabolic enzyme MAO. Iproniazid as well as other MAO inhibitors were soon shown to be effective in alleviating depression.

    The clinical and cellular actions of tricyclic antidepressants, such as amitriptyline, were considered to support the monoamine hypothesis of mood disorders. These drugs, resulting from a modification of the phenothiazine nucleus, were found to alleviate depression consistently, as did the MAO inhibitors. Their major cellular action is to block the reuptake by presynaptic terminals of monoamine transmitters, thereby, presumably, increasing the concentration of monoamines available to interact with synaptic receptors. Thus, the actions of reserpine, MAO inhibitors and tricyclics were initially thought to be consistent in supporting the monoamine hypothesis.

    Inconsistencies arose, however. The pharmacological activities of several other clinically effective compounds are difficult to reconcile with the monoamine hypothesis. Several antidepressant agents do not significantly inhibit MAO or block the reuptake of monoamines. The antimanic agent lithium (discussed below) can also be used to treat depression, yet it does not chronically increase synaptic concentrations of monoamines. Conversely, cocaine, a potent inhibitor of monoamine reuptake, has no antidepressant activity.

    More detailed examination of the actions of reserpine, MAO inhibitors and tricyclics also reveals inconsistencies among their actions. Reserpine induces depression in only about 6% of patients, an incidence quite similar to the estimated incidence of depression in the general population. More importantly, the cellular effects of MAO inhibitors and tricyclic antidepressants on catecholamines are immediate, yet their clinical antidepressant effects develop quite slowly, generally over 2 to 6 weeks.

    Attempts to directly measure changes in brain monoamine concentrations in the mood disorders have provided intriguing but inconsistent results. Initially, investigators concentrated on measuring the catecholamine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), in urine and CSF. Early evidence suggested that there were decreased urinary MHPG concentrations in depressed patients and increased levels in manic patients but later reports did not bear this out. This is not entirely surprising as it is now known that urinary MHPG is a poor indicator of CNS NE turnover because the CNS contributes as little as 20% of urinary MHPG content. In addition, MHPG concentrations are substantially affected by physical activity, which was often not well controlled in research studies. Concentrations of MHPG in the CSF, which may represent a more direct measure of brain NE function, have generally been found to be unaltered in mood disorders, although this remains a controversial area (see Chap. 12).

    Dopamine mechanisms may be important in some forms of depression and mania
    
    DA may also be involved in depression, and a body of literature suggests that there may be a subgroup of mood disorders in which the neuroregulator is altered [18–21]. DA receptor agonists have been reported to have some antidepressant effects in at least subgroups of patients. A number of antidepressant drugs also have DA agonist activities. Furthermore, patients in the DA-depleted state of Parkinson's disease (see Chap. 45) often develop a concomitant depression, although that may be for other reasons. Conversely, there is evidence linking DA to mania in certain patients. Several drugs that increase available amounts of DA produce behaviors that simulate some aspects of mania. Administration of levodopa (l-DOPA), the metabolic precursor of DA, can induce hypomania in some patients, a finding particularly noted in persons with bipolar disorder. In addition, DA antagonists are useful pharmacological treatments for mania, and there is evidence that DA synthesis inhibitors may also be effective. Neuroleptic drugs are also important agents for resolution of psychotic symptoms that occur in severe cases of both mania and depression [18]. However, there are problems with postulating a primary role for DA in the mood disorders. Most notably, neuroleptic medications that are known to block DA receptors and used to treat psychosis (Chap. 51) are not generally associated with the induction of depression. It is more likely that other, primary pathophysiological processes impact on dopaminergic systems, especially in more severe, psychotic forms of affective illness.

    Studies of the major metabolite of DA in CSF, homovanillic acid (HVA), have been somewhat inconsistent, suggesting decreased concentrations in at least some patients with depression. Comparison between studies has been difficult due to small sample size and differences among clinical populations, including age differences. A number of studies have suggested elevated concentrations of the metabolite in the CSF of manic individuals. However, metabolites for other transmitters were also elevated in some of these studies.

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47. After mt trip, i had the gift of Telepathy

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48. Psychedelics is a crap chemical that messes up your brain's wiring and that is the reason it is banned by governments all across the world, save your life guys and don't fall for this trap, believe me. Its long term consequences are horrendous…

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49. That is a very simplistic understanding (even though it seems to make sense to mainstream people who have a limited understanding of how the brain works).

    Yes, your brain gets “liberated” with the use of psychedelic, but it is the same way you get “liberated”when you are driving in your car and you go from having to follow the lanes on the highways & roads to driving in the midst of Indian traffic. Less rules are not necessarily better unless you enjoy the utter chaos.

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